artigo bioquimica

2425

Distribution of body fat and breast cancer: a case-control study in the South of Brazil

Jussara Beatriz Borre Felden 1
Andreia Cristina Leal Figueiredo 2

1

Departamento de Saúde
Coletiva, Universidade
Luterana do Brasil. Av.
Farroupilha 8001, prédio
14, sala 228, São José.
92425-900 Canoas RS. [e-mail] 2 Faculdade de Odontologia,
Universidade Federal da
Bahia.

Abstract The scope of this study is to verify the association between body fat distribution and breast cancer in women in the state of Rio Grande do Sul, Brazil. Case-control methodology was used in this study, in which 100 women with a histopathological diagnosis of breast cancer were compared to an out-patient control group (400 women) between January and October 2005. The anthropometric variables collected were: body mass
(kg), height, waist circumference (WC), and hip circumference. No association was found between the body mass index (BMI) and the waist/hip ratio (WHR) with the occurrence of breast cancer. In relation to WC, it was observed that women with a high measurement (> 88 cm) showed
2.08 times greater chance of developing the disease than those with normal or moderate measurements (< 80 cm–87 cm). When these women were grouped by (pre- and post-) menopausal state and anthropometric variables, only WC showed an adjusted OR association=3.15. The accumulation of fat in the upper part of the body (WC> 88 cm) is a predisposing factor for breast cancer, especially in pre-menopausal women.
Key words Anthropometry, Abdominal obesity,
Breast cancer, Case-control study

Resumo O presente estudo tem como objetivo verificar a associação entre a distribuição da gordura corporal e o câncer de mama em mulheres do Rio Grande do Sul. Para este estudo, utilizouse um delineamento de caso-controle, no qual foram avaliadas cem mulheres com diagnóstico histopatológico de câncer de mama em comparação com o grupo controle ambulatorial (400 mulheres) durante