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Abstract
OBJETO DO ESTUDO
Estudo de corte prospectivo
OBJETIVOS
Para caracterizar mudanças na cartilagem do joelho em indivíduos com osteoartrite no joelho (KOA), que tenham completado um programa de exercícios terapêuticos.

STUDY DESIGN
Prospective cohort study
OBJECTIVES
To characterize knee cartilage change in individuals with knee osteoarthritis (KOA) who have completed a therapeutic exercise program.
BACKGROUND
While therapeutic exercise is frequently used successfully to improve pain and function in individuals with KOA, no studies have reported the volume of cartilage change, or individual factors that may impact volume of cartilage change, in those completing an exercise program for KOA.
METHODS
13 individuals with KOA underwent magnetic resonance imaging (MR) to quantify cartilage volume change for the weight-bearing regions of the medial and lateral femoral condyles and the entire surface of the tibial plateaus from baseline to 1-year follow-up. Measurements of body structure and function and activity levels/limitations such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Physical Activity Scale for the Elderly (PASE) were performed prior to the therapeutic exercise program. At 6 months from baseline follow-up clinical measurements of knee strength and motion were performed. At 1-year from baseline, imaging of the knee cartilage, knee alignment, and the WOMAC and PASE questionnaires were completed.
RESULTS
The central region of the medial femoral condyle (cMF) had a median volume of cartilage loss of 3.8%. The other 3 knee tibiofemoral articular surfaces had minimal median cartilage volume change. Individuals were dichotomized into progressors (n=6) and non-progressors (n=7) based on the standard error of measurement (SEM) of cartilage volume change for the cMF. Progressors were younger, had a larger body mass index, had a higher Kellgren-Lawrence grade in the medial compartment of the knee, and had a