Informação

CLINICAL REVIEW

David W. Eisele, MD, Section Editor

EVIDENCE-BASED REVIEW OF TREATMENT OPTIONS FOR PATIENTS WITH GLOTTIC CANCER
Dana M. Hartl, MD, PhD,1,2 Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FHKCORL, FRCPath, FASCP, IFCAP,3 Daniel F. Brasnu, MD,4 Johannes A. Langendijk, MD, PhD,5 Alessandra Rinaldo, MD, FRCSEd ad hominem, FRCS (Eng, Ir) ad eundem, FRCSGlasg,3 Carl E. Silver, MD,6 Gregory T. Wolf, MD7
1

Department of Otolaryngology–Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France. E-mail: [e-mail] 2 ´ Laboratoire de Phonetique et de Phonologie, Sorbonne Nouvelle, Paris, France 3 Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy 4 Department of Otolaryngology–Head and Neck Surgery, and Voice, Biomaterials and Head and Neck Oncology Research Laboratory, University Paris V, European Hospital Georges Pompidou, Paris, France 5 Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 6 Departments of Surgery and Otolaryngology–Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 7 Department of Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan

Accepted 21 May 2010 Published online 6 January 2011 in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/hed.21528

Abstract: Evidence-based medicine integrates the best available data in decision making, with the goal of minimizing physicians’ and patients’ subjectivity. In 2006, the American Society of Clinical Oncology edited clinical practice guidelines for the use of larynx preservation strategies. The objective of this review was to evaluate the current levels of evidence for glottic squamous cell carcinoma. Current guidelines for early stage glottic cancer are based on low-level evidence. Conservation surgery (open or transoral) and radiation therapy