Freelancer
A RAID 0 can be created with disks of differing sizes, but the storage space added to the array by each disk is limited to the size of the smallest disk. For example, if a 100 GB disk is striped together with a 350 GB disk, the size of the array will be 200 GB (100 GB × 2).
\begin{align} \mathrm{Size} & = 2 \cdot \min \left( 100\,\mathrm{GB}, 350\,\mathrm{GB} \right) \\ & = 2 \cdot 100\,\mathrm{GB} \\ & = 200\,\mathrm{GB} \end{align}
The diagram shows the how data is distributed into Ax stripes to the disks. Accessing the stripes in the order A1, A2, A3, ... provides the illusion of a larger and faster drive. Once the stripe size is defined on creation it needs to be maintained at all times.
Performance
While the block size can technically be as small as a byte, it is almost always a multiple of the hard disk sector size of 512 bytes. This lets each drive seek independently when randomly reading or writing data on the disk. How much the drives act independently depends on the access pattern from the file system level. For reads and writes that are larger than the stripe size, such as copying files or video playback, the disks will be seeking to the same position on each disk, so the seek time of the array will be the same as that of a single drive. For reads and writes that are smaller than the stripe size, such as database access, the drives will be able to seek independently. If the sectors accessed are spread evenly between the two drives, the apparent seek time of the array will be half that of a single drive (assuming the disks in the array have identical access time