Transtorno obsessivo compulsivo
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Revista Brasileira de Psiquiatria
Print version ISSN 1516-4446
Rev. Bras. Psiquiatr. vol.23 suppl.2 São Paulo Oct. 2001 http://dx.doi.org/10.1590/S1516-44462001000600012 Aspectos genéticos do transtorno obsessivo-compulsivo
Christina H Gonzalez
Departamento de Psiquiatria da Universidade Federal de São Paulo/Escola Paulista de Medicina. São Paulo, SP, Brasil
ABSTRACT
Since the first descriptions of obsessive-compulsive disorder (OCD), genetic factors have been implicated in the etiology of the illness. Twin studies show a high concordance rate for monozygotic twins. Family studies found a higher risk for OCD among relatives of OCD patients. Segregation analysis studies suggest the possible role of a major effect gene in the etiology of OCD. Association studies using molecular techniques have been conducted to try to find a specific gene or polymorphism involved in OCD. This review outlines the evidence gathered to date, including the recent findings in the molecular genetics analysis.
Keywords: Obsessive-compulsive disorder. Etiology. Genetics. Genetic predisposition to