Parótida e aids

Oral Diseases (2003) 9, 55–61
Ó 2003 Blackwell Munksgaard

All rights reserved 1354-523X/03

http://www.blackwellmunksgaard.com

HIV Disease

Parotid gland involvement in advanced AIDS
¨
PA Vargas1, T Mauad2,3, GM Bohm2, PHN Saldiva2, OP Almeida1
1

Department of Oral Pathology, Faculty of Odontology of Piracicaba-University of Campinas, Piracicaba-SP; 2Department of Pathology, School of Medicine of Sa˜o Paulo-University of Sa˜o Paulo, Sa˜o Paulo-SP, Brazil; 3Department of Pulmonology,
Leiden University Medical Center, Leiden, the Netherlands

OBJECTIVE: This study describes the involvement and the histological alterations found in the parotid glands of
100 patients who died with AIDS.
MATERIALS AND METHODS: Sex, age, CD4 cell count and clinical history were obtained from the files of 100 patients who died with AIDS. Histological analysis of the parotid glands was performed using H&E, Gomori–
Grocott, Ziehl–Neelsen and Mucicarmine. Histological findings were grouped in reactive, infectious, cystic, neoplastic and concomitant lesions.
RESULTS: None of the patients presented complaints or symptoms related to salivary gland alterations prior to death. The mean age of the patients and CD4 cell count were 36.4 years and 76.07 cells ll)1, respectively.
Histological alterations of the parotid glands were found in 51% of the patients. The most common alteration was non-specific chronic sialadenitis (29 cases), followed by infectious conditions (22 cases).
Mycobacteriosis was the most common infectious disease (10 cases), followed by cytomegalovirus (nine cases), cryptococcosis (three cases) and histoplasmosis
(two cases). Lymphoepithelial cysts occurred in six cases, Warthin’s tumor and non-Hodgkin Lymphoma in one case each.
CONCLUSIONS: These results indicate that infection and other lesions in the parotid glands are more frequent than hitherto described in the specialized literature in AIDS patients. Clinicians should consider