Oxido nitrico, endotélio e processos patologicos

Artigo de Revisão

Óxido Nítrico, Endotélio e Processos Patológicos.
*Fernando Alves da Silva
**Prof° Msc. André Luiz dos Reis Barbosa
ABSTRACT:
Nitric oxide is a gas, which mediates many phenomena, since the vasodilation mediated toxicity by macrophages. Nitric oxide is the product of a redox reaction of L-arginine catalyzed by NOS who can be constructive or induced. Endothelial cells play an important role in controlling vascular tone, vascular permeability, metabolism of endogenous and exogenous substances. The NO produced by endothelial cells plays an important role in controlling vascular resistance and platelet aggregation therefore has significant control of blood pressure and, in addition, NO is a potent inhibitor of platelet aggregation, thereby preventing thrombus formation and consequently, thrombosis. It is clear participation of NO in pathological events such as hypertension and thrombosis, but the main argument is that NO has a biphasic role in platelet activation, although at low concentrations stimulates platelet activation, and high concentrations, inhibits platelet activation. Conclusion, the beneficial action of NO on BP control and formation of thrombus is established and closely linked to an intact endothelium, which guarantees a sufficient bioavailability of NO that can act in the maintenance of hemostasis.

Keywords: nitric oxide, endothelium, hypertension, exercise and stroke.

Ouvir
Ler foneticamente
Resumo:

O óxido nítrico é um gás, que medeia vários fenômenos, desde a vasodilatação a toxicidade mediada por macrófagos. O óxido nítrico, é o produto de uma reação redox da L-arginina catalisada pelas NOS que podem ser: constitutiva ou induzida. As células endoteliais desempenham um papel relevante no controle do tônus vascular, permeabilidade vascular, metabolismo de substâncias endógenas e exógenas. O NO produzido pelas células endoteliais desempenha um importante papel tanto no controle da resistência vascular e agregação