1413 8123 csc 19 09 3799

DOI: 10.1590/1413-81232014199.01532013

Vaccines as an agent for immunization against HPV

Geisa Picksius Zardo 1
Flávia Peixoto Farah 1
Fernanda Gabriela Mendes 1
Camila Ament Giuliani dos Santos Franco 1
Giseli Vieira Machado Molina 1
Gislaine Nochetti de Melo 1
Solena Ziemer Kusma 1

Abstract Considered a highly prevalent infection throughout the world, the human papillomavirus
(HPV) is a DNA virus that infects the genital mucosa and has high carcinogenic potential, being related to an increased risk of lower genital tract lesions, such as cervical cancer. This cancer is responsible for the deaths of about 231,000 women per year worldwide, which means that HPV is a major problem for public health. Knowing that the most effective and cost-effective way to control an infectious disease is the development of vaccines, two prophylactic vaccines have been developed and approved in Brazil, one of which is bivalent and the other is tetravalent. This review of the literature seeks to present the characteristics of the
HPV virus, types of vaccines available on the market, their indications and contraindications, their adverse effects, their effectiveness, their geometric mean titer (GMT) and their cost-effectiveness.
Key words Human papillomavirus, HPV vaccination, Public health

1
Reitoria, Pontifícia
Universidade Católica do Paraná. R. Imaculada
Conceição, Prado Velho.
80.215-901 Curitiba PR
Brasil.
[e-mail]

Resumo Considerada uma infecção de alta prevalência em todo o mundo, o papiloma vírus humano (HPV) é um DNA vírus que infecta a mucosa genital e possui grande potencial oncogênico, sendo relacionado ao risco aumentado de lesões do trato genital inferior, como o câncer cervical. Este câncer é responsável pela morte de cerca de 231 mil mulheres por ano no mundo, o que torna o
HPV um grande problema para a saúde pública.
Sabendo que a maneira mais eficaz e com melhor custo-benefício para controlar uma doença infecciosa é o desenvolvimento de vacinas,