Harmonized guidelines for singlelaboratory validation of methods of analysis

language is subject to the additional condition of prior approval from the relevant IUPAC National Adhering Organization. 835 M. THOMPSON et al. 836 Harmonized guidelines for single-laboratory validation of methods of analysis (IUPAC Technical Report) Abstract: Method validation is one of the measures universally recognized as a necessary part of a comprehensive system of quality assurance in analytical chemistry. In the past, ISO, IUPAC, and AOAC International have cooperated to produce agreed protocols or guidelines on the “Design, conduct and interpretation of method performance studies” [1], on the “Proficiency testing of (chemical) analytical laboratories” [2], on “Internal quality control in analytical chemistry laboratories” [3], and on “The use of recovery information in analytical measurement” [4]. The Working Group that produced these protocols/guidelines has now been mandated by IUPAC to prepare guidelines on the single-laboratory validation of methods of analysis. These guidelines provide minimum recommendations on procedures that should be employed to ensure adequate validation of analytical methods. A draft of the guidelines has been discussed at an International Symposium on the Harmonization of Quality Assurance Systems in Chemical Laboratory, the proceedings from which have been published by the UK Royal Society of Chemistry. CONTENTS 1. INTRODUCTION 1.1 Background 1.2 Existing protocols, standards, and guides 2.…

pacientes durante a dispensação de medicamentos e durante o acompanhamento farmacoterapêutico; - Educação Continuada 18 21 REFERÊNCIAS • • • • • • • • • • Effects of preanalytical variables on clinical laboratory tests. 2nd ed. Donald S. Young, AACC Pres, 1997. Effects of drugs on clinical laboratory tests. 4th edição. Donald S. Young, AACC Pres, 1995. Effects of disease on clinical laboratory tests. 4th ed. Donald S. Young, AACC Pres, 2001. Guder, W. G. e…

Periodic Properties of the Elements Note to the Instructor: This laboratory experiment may be split into two laboratory periods, and can be done solo as a DEMONSTRATION. Purpose: The purpose of this lab is to observe how certain properties of elements tend toward a periodic similarity when the elements are arranged in order of increasing atomic number; to note that elements (and ions of those elements) in the same vertical column (family) of the periodic table have similar…

Regulations for Clinical Laboratory Operation. ANVISA; 2005. 4.  Girelli WF, Silva PH, Fadel-Picheth CM, Picheth G. Biological variability in hematological quantities. RBAC2004;36(1):23-7. 5.  PICHETH G, SCARTEZINI M, ALCÂNTARA VM, MONTEIRO RA, MARIANO C, JAWORSKI MCG, et al. Quanto podem variar duas determinações sucessivas de triglicérides? Laes & Haes2001;6(128):174-90. 6.  Sebastian-Gambaro MA, Liron-Hernandez FJ, Fuentes-Arderiu X. Intra- and inter-individual biological…

Technical Regulations for Clinical Laboratory Operation. ANVISA; 2005. 4. Girelli WF, Silva PH, Fadel-Picheth CM, Picheth G. Biological variability in hematological quantities. RBAC2004;36(1):23-7. 5. PICHETH G, SCARTEZINI M, ALCÂNTARA VM, MONTEIRO RA, MARIANO C, JAWORSKI MCG, et al. Quanto podem variar duas determinações sucessivas de triglicérides? Laes & Haes2001;6(128):174-90. 6. Sebastian-Gambaro MA, Liron-Hernandez FJ, Fuentes-Arderiu X. Intra- and inter-individual…

1976;294:925-930 8) Durbridge TC, Edwards F, Edwards RG, Atkison M. Evaluation of benefits of screening tests done immediately on admission to hospital. Clin Chem 1976;22:968-971. 9) Narr BJ, Hansen TR, Warner MA. Preoperative laboratory screening in healthy Mayo patients: cost- effective elimination of tests and unchanged outcomes. Mayo Clin Proc 1991;66:155-159. 10) Robertson WM. Medical malpractice: a preventive aproach. Seattle: University of Washington Press, 1985 11) Delahunt B,…

laboratório clínico Abstract: The present study was performed at the Laboratory of Unimed Hospital in Sorocaba (LUS) with the objective to evaluate the applicability and benefits of the Information Technology (IT), in technical and financial-administrative management, through indicators of performance (production, productivity and recollection), quality (satisfaction research of patients and medical) and economical (costs). With the introduction of the Laboratory Information System…

Technological Diffusion Entomology Breeding. Our structure Coodetec is headquartered in Cascavel (PR), which maintains headquarters, whose structure includes a training center, genetic laboratory soy, wheat and corn, laboratory analysis of soils, molecular biology laboratories, a physical chemist and plant pathology, laboratory analysis of seeds, dry chambers, greenhouses, among others. Other Research Centers are located in Palotina (PR), Rio Verde (GO ) and Primavera do Leste…

steam-solvent processes, when fully developed, will extract oil at lower cost than SAGD and will also open currently marginal resources for exploitation, increasing oil reserves. This paper presents and discusses the principal concepts and key parameters for the new hybrid steam-solvent processes and compares expected performance to SAGD. Introduction The goal of this paper is to provide a summary of the hybrid steam-solvent processes developed at the Alberta Research Council (ARC),…

Physical Fitness and Performance The Effect of Carbohydrate Mouth Rinse on 1-h Cycle Time Trial Performance JAMES M. CARTER, ASKER E. JEUKENDRUP, and DAVID A. JONES Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham, UNITED KINGDOM ABSTRACT CARTER, J. M., A. E. JEUKENDRUP, and D. A. JONES. The Effect of Carbohydrate Mouth Rinse on 1-h Cycle Time Trial Performance. Med. Sci. Sports Exerc., Vol. 36, No. 12, pp.…