Ditiocarbamates and nitric oxide

Polyhedron 25 (2006) 3366–3378 www.elsevier.com/locate/poly

Studies of the interaction between bis(dithiocarbamato)copper(II) complexes with nitric oxide in aqueous solution and biological applications
´ Agostinho Cachapa a, Alfredo Mederos a,*, Pedro Gili a, Rita Hernandez-Molina a, a a b ´ ´ ´ ´ Sixto Domınguez , Erasmo Chinea , Matıas Lopez Rodrıguez , Marta Feliz c, c d Rosa Llusar , Felipe Brito , Carlos M. Ruiz de Galarreta e, ´ Carlos Tarbraue e, German Gallardo e a ´ ´ Departamento de Quımica Inorganica, Facultad de Farmacia, Universidad de La Laguna, 38200 La Laguna, Tenerife, Canary Islands, Spain b ´ ´ Instituto Universitario de Bioorganica ‘‘A. Gonzalez’’, Universidad de La Laguna, Tenerife, Canary Islands, Spain c ´ Departamento de Ciencias Experimentales, Universitat Jaime I, Castellon, Spain d ´ ´ Centro de Equilibrios en Solucion, Escuela de Quımica, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela e ´ ´ ´ Departamento de Bioquımica, Biologıa Molecular y Fisiologıa, Facultad de Medicina, Universidad de Las Palmas de Gran Canaria, Gran Canaria, Canary Islands, Spain Received 27 February 2006; accepted 12 June 2006 Available online 16 June 2006

Abstract Three new bis(dithiocarbamato)copper(II) complexes have been prepared and characterized by elemental analysis, UV–Vis, and IR spectroscopy: bis(4-piperidonedithiocarbamato)copper(II), [Cu(Pdtc)2]2 (1), bis(piperidinedithiocarbamato)copper(II), [Cu(Ppdtc)2]2 (2), and bis[(2-piperidinecarboxy)dithiocarbamato]copper(II), Cu(Ppidtc)2 (3). The crystal structures of the complexes 1 and 2 have been determined using X-ray diffraction methods and they are dimeric. The coordination sphere of copper(II) ions is described as a distorted ˚ ˚ square-pyramid: the axial Cu–S bond distances 2.7 and 2.8 A for 1 and 2, respectively, are longer than the equatorial Cu–S ones (2.3 A). Complexes 1 and 2 are not soluble in water. In contrast, 3 is water soluble. The interaction of 3, the