Estresse inflamação e alteração cognitiva

Oxid Antioxid Med Sci 2012; 1(3):169-173

ISSN: 2146-8389

Oxidants and Antioxidants in Medical Science available at www.scopemed.org

Brief Report

Association of biomarkers for inflammation, endothelial dysfunction and oxidative stress with cognitive impairment: the Epidemiology of Hearing Loss Study
Chidi N. Obasi1, Karen J. Cruickshanks1,2, David M. Nondahl2,
Barbara E. K. Klein2, Ronald Klein2, F. Javier Nieto1, Anoop Shankar5,
Mary E. Fischer2, Michael Y. Tsai6, Rick Chappell3,4,
1

Department of Population Health Sciences, 2Department of Ophthalmology and Visual Sciences,
3
Department of Statistics, and 4Department of Biostatistics and Medical Informatics;
University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI , USA
5
Department of Community Medicine, West Virginia University School of Medicine, Morgantown, WV, USA
6
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Received November 2, 2012
Accepted December 3, 2012
Published Online December 19, 2012
DOI 10.5455/oams.031212.br.004
Corresponding Author
Chidi N. Obasi
Department of Family Medicine,
University of Wisconsin-Madison,
1100 Delaplaine Ct.,
Madison, WI 53715, USA. [e-mail] Key Words
Biomarkers; Cognitive impairment;
Inflammation; Oxidative stress

Abstract
Individual biomarkers of inflammation, endothelial dysfunction and oxidative stress have been associated with cognitive impairment. This study explored whether a combination of biomarkers could prospectively identify those who developed cognitive decline. Biomarkers were obtained during the baseline examination of the Beaver Dam Eye Study (1988 -90), and cognitive status was assessed during the 5-year follow-up examination of the Epidemiology of Hearing Loss
Study (1998-2000). Cognitive impairment was defined as a score of < 24 points on the MiniMental State Examination or self- or proxy report of Alzheimer Disease or