Artigo fitoquimica

Experimental Parasitology 132 (2012) 123–128

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Experimental Parasitology journal homepage: www.elsevier.com/locate/yexpr

Trypanocidal and cytotoxic activities of essential oils from medicinal plants of Northeast of Brazil
Andrezza Raposo Borges a, Juliana Ramos de Albuquerque Aires a, Taciana Mirely Maciel Higino a,
Maria das Graças Freire de Medeiros b, Antonia Maria das Graças Lopes Citó b,
José Arimatéia Dantas Lopes b, Regina Celia Bressan Queiroz de Figueiredo a,⇑ a b

Departamento de Microbiologia, Centro de Pesquisa Aggeu Magalhães, FIOCRUZ, PE, Av. Prof. Moraes Rego s/n Cidade Universitária-Campus da UFPE, Recife-PE, 50670-420, Brazil
Departamento de Química, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portela-Ininga, Teresina-PI, 64049-550, Brazil

highlights

graphical abstract

" The trypanocidal potential of

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essential oils from medicinal plants was evaluated.
The essential oils tested were active against all evolutive forms of
Trypanosoma cruzi.
The essential oil from Lippia sidoides was the most effective against trypomastigotes. Lippia origanoides essential oil was the most effective against amastigotes. All essential oils were more specific against parasites than mammal cells.

article

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Article history:
Received 26 January 2012
Received in revised form 12 June 2012
Accepted 13 June 2012
Available online 4 July 2012
Keywords:
Essential oils
Trypanosoma cruzi
Chagas disease
Chemotherapy
Cytotoxicity

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abstract
Chagas disease, caused by Trypanosoma cruzi, is an important cause of mortality and morbidity in Latin
America. There are no vaccines available, the chemotherapy used to treat this illness has serious side effects and its efficacy on the chronic phase of disease is still a matter of debate. In a search for alternative treatment for Chagas disease, essential oils extracted from